Publications

2023-08: Raghavan K, Sivakumar T, Ichiyama K, Yamamoto N, Balamurugan M, Dedeepiya VD, Senthilkumar R, Preethy S, Abraham S. Efficacy of N-163 beta-glucan in beneficially improving biomarkers of relevance to muscle function in patients with muscular dystrophies in a pilot clinical study. Acta Myologica 2023. 2023 Dec 20; doi: 10.36185/2532-1900-312

2023-07: Preethy S, Aoki Y, Minegishi K, Iwasaki M, Senthilkumar R, Abraham S. Resolution of fibrosis in mdx dystrophic mouse after oral consumption of N-163 strain of Aureobasidium pullulans produced β-glucan. Sci Rep 13, 17008 (2023). doi: 10.1038/s41598-023-44330-0

2023-06: Raghavan K, Dedeepiya VD, Srinivasan S, Pushkala S, Subramanian S, Ikewaki N, Iwasaki M, Senthilkumar R, Preethy S, Abraham S. Beneficial immune-modulatory effects of the N-163 strain of Aureobasidium pullulans-produced 1,3-1,6 Beta glucans in Duchenne muscular dystrophy: Results of an open-label, prospective, exploratory case-control clinical study. IBRO Neuroscience reports 2023; 15: 90-99. doi: 10.1016/j.ibneur.2023.06.007.

2023-05: Ikewaki N, Sonoda T, Kurosawa G, Iwasaki M, Dedeepiya VD, Senthilkumar R, Preethy S, Abraham S . Beta 1,3-1,6 glucans produced by two novel strains of Aureobasidium pullulans exert immune and metabolic beneficial effects in healthy middle-aged Japanese men: Results of an exploratory randomized control study. J Aging Res & Lifestyle 2023;12:61-71. doi: 10.14283/jarlife.2023.11.

2023-04: Kadalraja Raghavan, Vidyasagar Devaprasad Dedeepiya, Subramaniam Srinivasan, Subramanian Pushkala, Sudhakar S. Bharatidasan, Nobunao Ikewaki, Masaru Iwasaki, Rajappa Senthilkumar, Senthilkumar Preethy, Samuel J.K. Abraham. Beneficial immune-modulatory effects of the N-163 strain of Aureobasidium pullulans-produced 1,3-1,6 Beta glucans in Duchenne muscular dystrophy: Results of an open-label, prospective, exploratory case-control clinical study. IBRO Neuroscience Reports 15 (2023) 90-99. doi : 10.1016/j.ibneur.2023.06.007.

2023-03: S Preethy , N Yamamoto , N Liem , S Bharatidasan , M Iwasaki , S Abraham . Role of gut microbiome homeostasis, integrity of the intestinal epithelial cells, and the (endogenous) butyrate in enduring a healthy long life. GEORGIAN MEDICAL NEWS No 3 (336) 2023. Pubmed - PMID: 37166884.

2023-02:Samuel JK Abraham, Kadalraja Raghavan, Thanasekar Sivakumar, Sudhakar S Bharathidasan, Subramaniam Srinivasan, Vidyasagar Devaprasad Dedeepiya, Nobunao Ikewaki, Masaru Iwasaki, Rajappa Senthilkumar, Senthilkumar Preethy. Efficacy of a safe ß-glucan in improving muscle function in Duchenne Muscular Dystrophy; results of a 6-month nonrandomized open-label extension trial. MDA Conference 2023.

2023-01:Samuel JK Abraham, Shuji Sakamoto, Takuma Higuchi, Subramaniam Srinivasan, Vidyasagar Devaprasad Dedeepiya, Nobunao Ikewaki, Masaru Iwasaki, Mathaiyan Rajmohan, Rajappa Senthilkumar, Senthilkumar Preethy. Enhanced muscle regeneration in MDX Duchenne muscular dystrophy-mice, proven by CD44 & MYH3, on consumption of A.Pullulans produced Neu REFIX ß-Glucan. MDA Conference 2023.

2022-08: Ikewaki N, Ikeue Y, Nagataki M, Kurosawa G, Dedeepiya VD, Rajmohan M, Suryaprakash V, Senthilkumar R, Preethy S. Abraham SJK. Beneficial effects of 1,3–1,6 β-glucans produced by Aureobasidium pullulans on non-esterified fatty acid levels in diabetic KKAy mice and their potential implications in metabolic dysregulation. J Diabetes Metab Disord (2022) doi: 10.1007/s40200-022-01170-5.

 

2022-07: Preethy S, Raghavan K, Ikewaki N, Abraham SJ. Qualitative Evaluation of α-Synuclein - A Critical Step in Unraveling the Complexities of Autism Spectrum Disorder. Med Princ Pract. 2022 Oct 29. doi: 10.1159/000527728.

2022-06: Raghavan K, Dedeepiya VD, Yamamoto N, Ikewaki N, Sonoda T, Iwasaki M, Kandaswamy R, Senthilkumar R, Preethy S, Abraham SJK. Benefits of gut microbiota reconstitution by beta 1,3-1,6 glucans in subjects with autism spectrum disorder and other neurodegenerative diseases. Journal of Alzheimer's Disease.1 Jan. 2022 : 1 – 12. doi: 10.3233/JAD-220388

 

2022-05: Raghavan K, Dedeepiya VD, Kandaswamy R, Balamurugan M, Ikewaki N, Sonoda T, Kurosawa G, Iwasaki M, Preethy S, Abraham SJK. Improvement of sleep patterns and serum melatonin levels in children with autism spectrum disorders after consumption of beta-1,3/1,6-glucan in a pilot clinical study. Brain and Behaviour. doi: 10.1002/brb3.2750

 

2022-04: Preethy S, Ikewaki N, Levy GA, Raghavan K, Dedeepiya VD, Yamamoto N, Srinivasan S, Ranganathan N, Iwasaki M, Senthilkumar R, Abraham SJK. RTwo unique biological response-modifier glucans beneficially regulating gut microbiota and faecal metabolome in a non-alcoholic steatohepatitis animal model, with potential for applications in human health and disease. BMJ Open Gastroenterology 2022;9:e000985. doi: 10.1136/bmjgast-2022-000985

 

2022-03: Ikewaki N, Ikeue Y, Nagataki M, Kurosawa G, Dedeepiya VD, Rajmohan M, Suryaprakash V, Senthilkumar R, Preethy S. Abraham SJK. Beneficial effects of 1,3–1,6 β-glucans produced by Aureobasidium pullulans on non-esterified fatty acid levels in diabetic KKAy mice and their potential implications in metabolic dysregulation. J Diabetes Metab Disord (2022). doi: 10.1007/s40200-022-01170-5

2022-02: Ikewaki N, Kurosawa G, Iwasaki M, Preethy S, Dedeepiya VD, Vaddi S, Senthilkumar R, Levy GA, Abraham SJK. Hepatoprotective effects of Aureobasidium pullulans derived Beta 1,3-1,6 biological response modifier glucans in a STAM- animal model of non-alcoholic steatohepatitis. Journal of Clinical and Experimental Hepatology.2022. doi: 10.1016/j.jceh.2022.06.008

2022-01: Raghavan K, Dedeepiya VD, Ikewaki N, Sonoda T, Iwasaki M, Preethy S, Abraham SJK. Improvement of behavioural pattern and alpha-synuclein levels in autism spectrum disorder after consumption of a beta-glucan food supplement in a randomized, parallel-group pilot clinical study. medRxiv 2021.06.28.21259619; doi: 10.1101/2021.06.28.21259619

2021-05: Ikewaki N, Raghavan K, Dedeepiya VD, Suryaprakash V, Iwasaki M, Preethy S, senthilkumar R, Abraham SJK.Beneficial immune-regulatory effects of novel strains of Aureobasidium pullulans AFO-202 and N-163 produced beta glucans in Sprague Dawley rats. Clinical Immunology Communications 2021.

2021-04: Ikewaki N, Dedeepiya VD, Raghavan K, Rao K, Vaddi S, Osawa H, Kisaka T, Kurosawa G, Srinivasan S, Ganesakumar SRB, Senthilkumar R, Iwasaki M, Preethy S, Abraham SJK. β‑glucan vaccine adjuvant approach for cancer treatment through immune enhancement (B‑VACCIEN) in specific immunocompromised populations (Review). Oncol Rep 47: 14, 2022 doi.org/10.3892/or.2021.8225

2021-03: Raghavan K, Dedeepiya VD, Suryaprakash V, Rao KS, Ikewaki N, Sonoda T, Levy GA, Iwasaki M, Senthilkumar R, Preethy S, Abraham SJK. Beneficial Effects of novel Aureobasidium Pullulans strains produced Beta-1,3-1,6 Glucans on Interleukin-6 and D-Dimer levels in COVID-19 patients; results of a randomized multiple-arm pilot clinical study. Biomedicine & Pharmacotherapy, Article 112243, doi: 10.1101/2021.08.09.21261738

2021-02:Ikewaki N, Iwasaki M, Kurosawa G, Rao KS, Beitia JL, Preethy S, Abraham SJK. β-Glucans: Wide-spectrum Immune-balancing Food-supplement-based Enteric (β-WIFE) Vaccine Adjuvant Approach to COVID-19. Human Vaccines & Immunotherapeutics 2021; 17(9). doi:10.1080/21645515.2021.1880210.

2021-01:Ikewaki N, Dedeepiya VD, Iwasaki M, Abraham SJK. General Commentary: Beyond "TRIM" benefits of β-glucan by blood glucose and lipid balancing potentials in its defense Against COVID-19. doi: 10.3389/fimmu.2021.620658

2020-03:Rao K-S, Suryaprakash V, Senthilkumar R, Preethy S, Katoh S, Ikewaki N, Abraham SJK. Role of Immune Dysregulation in Increased Mortality Among a Specific Subset of COVID-19 Patients and Immune-Enhancement Strategies for Combatting Through Nutritional Supplements. Front. Immunol. 2020; 11:1548. doi: 10.3389/fimmu.2020.01548.

2020-02:Ikewaki N, Rao KS, Archibold AD, Iwasaki M, Senthilkumar R, Preethy S, Katoh S, Abraham SJK. Coagulopathy associated with COVID-19 – Perspectives & Preventive strategies using a Biological Response Modifier Glucan. Thromb J. 2020. doi: 10.1186/s12959-020-00239-6

2020-01:Ikewaki N, Iwasaki M, Abraham SJK. Biological response modifier glucan through balancing of blood glucose may have a prophylactic potential in COVID-19 patients. Journal of Diabetes & Metabolic Disorders 2020. doi: 10.1007/s40200-020-00664-4

2014-01:Ikewaki N, Iwasaki M, Abraham SJK. Beneficial effects of Black yeast derived 1-3, 1-6 beta glucan- Nichi Glucan in a dyslipidemic individual of Indian origin A case report. J Diet Suppl. 2014;11(1):1-6. doi:10.3109/19390211.2013.859211.

2012-01:Dedeepiya V, Sivaraman G,Venkatesh A, Preethy S, Abraham SJK. Potential Effects of Nichi Glucan as a Food Supplement for Diabetes Mellitus and Hyperlipidemia; Preliminary Findings from the Study on Three Patients from India. Case Reports in Medicine 2012 (2012), Article ID 895370;. doi:10.1155/2012/895370.

Preprints

 

 

Preprint 10: Preethy S, Aoki Y, Minegishi K, Iwasaki M, Senthilkumar R, Abraham S. Resolution of fibrosis in mdx dystrophic mouse after oral consumption of N-163 strain of Aureobasidium pullulans produced β-glucan. Scientific Reports 2023.

 

Preprint 09: Senthilkumar Preethy, Naoki Yamamoto, Kottoorathu Mammen Cherian, Rajasekaran Premsekar, Gary A Levy, Rajappa Senthilkumar, Samuel JK Abraham. Reduction in myocardial fibrosis in MDX mice on oral consumption of Aureobasidium Pullulans produced Neu REFIX Beta-glucans; holds potential as an adjuvant in managing post-transplantation organ fibrosis. biorxiv: 10.1101/2023.09.25.559276v1. doi : 10.1101/2023.09.25.559276.

 

Preprint 08: Senthilkumar Preethy, Shuji Sakamoto, Takuma Higuchi, Koji Ichiyama, Naoki Yamamoto, Nobunao Ikewaki, Masaru Iwasaki, Vidyasagar Devaprasad Dedeepiya, Subramaniam Srinivasan, Mathaiyan Rajmohan, Rajappa Senthilkumar, Samuel JK Abraham. Enhanced muscle regeneration in mdx mice, Duchenne muscular dystrophy animal model, proven by CD44 & MYH3 expression, on oral feeding of N-163 strain of Aureobasidium Pullulans produced B-Glucan. biorxiv 2023.06.06.543858v1 doi: 10.1101/2023.06.06.543858.

 

Preprint 07: Vidyasagar Devaprasad Dedeepiya, Chockanathan Vetrievel, Nobunao Ikewaki, Koji Ichiyama, Naoki Yamamoto, Hiroto Kawashima, Sudhakar S Bharatidasan, Subramaniam Srinivasan, Rajappa Senthilkumar, Senthilkumar Preethy, Samuel JK Abraham. Improvement in Expanded Disability Status Scale (EDSS) and anti-inflammatory parameters in patients with multiple sclerosis following oral consumption of N-163 strain of Aureobasidium pullulans produced beta glucan in a pilot clinical study. medRxiv 2023.05.14.23289953v2; doi: 10.1101/2023.05.14.23289953.

 

Preprint 06: Kadalraja Raghavan, Thanasekar Sivakumar, Sudhakar S Bharatidasan, Subramaniam Srinivasan, Vidyasagar Devaprasad Dedeepiya, Nobunao Ikewaki, Rajappa Senthilkumar, Senthilkumar Preethy, Samuel JK Abraham. Efficacy of N-163 strain of Aureobasidium pullulans-produced beta-glucan in improving muscle strength and function in patients with Duchenne muscular dystrophy; Results of a 6-month non-randomised open-label linear clinical trial. medRxiv 2023.04.29.23289260v1; doi: 10.1101/2023.04.29.23289260.

 

Preprint 05: Chockanathan Vetrievel, Allimuthu Nithyanandam, Subramaniam Srinivasan, Sudhakar S Bharatidasan, Vidyasagar Devaprasad Dedeepiya, Nobunao Ikewaki, Masaru Iwasaki, Rajappa Senthilkumar, Senthilkumar Preethy, Samuel JK Abraham. Evaluation of the disease modifying effects of Aureobasidium pullulans AFO 202 strain produced Beta Glucan in Parkinsons disease Results of a pilot clinical study. medRxiv 2023.04.14.23288571v1; doi: 10.1101/2023.04.14.23288571.

 

Preprint 04: Raghavan K, Dedeepiya VD, Yamamoto N, Ikewaki N, Iwasaki M, Dinassing A, Senthilkumar R, Preethy S, Abraham SJK. QualitatRandomised trial of Aureobasidium pullulans-produced beta 1,3-1,6-glucans in patients with Duchenne muscular dystrophy: Favourable changes in gut microbiota and clinical outcomes indicating their potential in epigenetic manipulation. medRxiv 2022.12.09.22283273; doi: 10.1101/2022.12.09.22283273.

 

Preprint 03: Preethy S, Aoki Y, Minegishi K, Iwasaki M, Senthilkumar R, Abraham S. Resolution of fibrosis in mdx dystrophic mouse after oral consumption of N-163 strain of Aureobasidium pullulans produced biological response modifier β-glucan (BRMG). bioRxiv 2022.; doi: 2022.11.17.516628

 

Preprint 02: Pushkala S, Seshayyan S, Theranirajan E, Sudhakar D, Raghavan K, Dedeepiya VD, Ikewaki N,Iwasaki M, Preethy S, Abraham S. Efficient control of IL-6, CRP and Ferritin in Covid-19 patients with two variants of Beta-1,3-1,6 glucans in combination, within 15 days in an open-label prospective clinical trial. medRxiv 2021.12.14.21267778; doi: 10.1101/2021.12.14.21267778

Preprint 01: Ikewaki N, Sonoda T, Kurosawa G, Iwasaki M, Dedeepiya VD, Senthilkumar R, Preethy S, Abraham SJK. Immune and metabolic beneficial effects of Beta 1,3-1,6 glucans produced by two novel strains of Aureobasidium pullulans in healthy middle-aged Japanese men: An exploratory study. medRxiv 2021.08.05.21261640; doi: 10.1101/2021.08.05.21261640

Presentations

 

 

8-10 Aug, 2024: Abraham S, Tsukada A, Miyajima I, Uchiyama S, Tabe D, Ikewaki N, Ichiyama K, Senthilkumar R, Iwasaki M. Effects of Aureobasidium Pullulans produced β-1,3-1,6-glucan on CA19-9, sCD44, IgA and sCD209 in patients undergoing surgical resection of malignant pancreatic tumors. (ASCO Breakthrough meeting abstract; Embargo till 08, August, 2024; J Clin Oncol 42, 2024 (suppl 23; abstr 96).

25, July 2024: Abraham S et al. Beneficial modulation of gut microbiome and Neutrophil-Lymphocyte ratio (NLR) by Nichi Glucan and its potentials as an adjuvant in malignant tumors of the pancreas and liver. 61st Annual Meeting of the Japanese Society of Surgical Metabolism and Nutrition. Osaka, Japan.